D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription

• Main Authors: Yaxin Guo (Author), Nuo Chen (Author), Ming Zhao (Author), Baihui Cao (Author), Faliang Zhu (Author), Chun Guo (Author), Yongyu Shi (Author), Qun Wang (Author), Yan Li (Author), Lining Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CREB-regulated transcription coactivator 1 (CRTC1), a pivotal synaptonuclear messenger, regulates synaptic plasticity and transmission to prevent depression. Despite exhaustive investigations into CRTC1 mRNA reductions in the depressed mice, the regulatory mechanisms governing its transcription rema...