Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

• Главные авторы: David Falck (Автор), Martin Lechmann (Автор), Ana Momčilović (Автор), Marco Thomann (Автор), Carolien A. M. Koeleman (Автор), Cordula Jany (Автор), Sebastian Malik (Автор), Manfred Wuhrer (Автор), Dietmar Reusch (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
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A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, which are considered a critical quality attribute beca...