Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

• Main Authors: David Falck (Author), Martin Lechmann (Author), Ana Momčilović (Author), Marco Thomann (Author), Carolien A. M. Koeleman (Author), Cordula Jany (Author), Sebastian Malik (Author), Manfred Wuhrer (Author), Dietmar Reusch (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, which are considered a critical quality attribute beca...