Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

• Main Authors: Xiaoshan Min (Author), Junming Yie (Author), Jinghong Wang (Author), Ben C. Chung (Author), Ching-Shin Huang (Author), Haoda Xu (Author), Jie Yang (Author), Liying Deng (Author), Joanne Lin (Author), Qing Chen (Author), Christina M. Abbott (Author), Caroline Gundel (Author), Stephen A. Thibault (Author), Tina Meng (Author), Darren L. Bates (Author), David J. Lloyd (Author), Murielle M. Véniant (Author), Zhulun Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological intervention of GIPR, however, has limited success...