Differences in type I interferon signaling antagonism by dengue viruses in human and non-human primate cell lines.

• Main Authors: Freddy A Medina (Author), Giselle Torres-Malavé (Author), Amanda J Chase (Author), Gilberto A Santiago (Author), Juan F Medina (Author), Luis M Santiago (Author), Jorge L Muñoz-Jordán (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND/OBJECTIVES:In vitro studies have shown that dengue virus (DENV) can thwart the actions of interferon (IFN)-α/β and prevent the development of an antiviral state in infected cells. Clinical studies looking at gene expression in patients with severe dengue show a reduced expression of inter...