New Diarylamine K_V10.1 Inhibitors and Their Anticancer Potential

• Main Authors: Špela Gubič (Author), Žan Toplak (Author), Xiaoyi Shi (Author), Jaka Dernovšek (Author), Louise Antonia Hendrickx (Author), Ernesto Lopes Pinheiro-Junior (Author), Steve Peigneur (Author), Jan Tytgat (Author), Luis A. Pardo (Author), Lucija Peterlin Mašič (Author), Tihomir Tomašič (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Expression of the voltage-gated potassium channel K_V10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A new structural class of K_V10.1 inhibitors was prepared by struc...