Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability
Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 position of pyrimidine. This strategy provided a...
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| Formaat: | Boek |
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Elsevier,
2023-07-01T00:00:00Z.
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A1234.567 |
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| Kopie 1 | Beschikbaar |