Machine learning model for anti-cancer drug combinations: Analysis, prediction, and validation

• Main Authors: Jing-Bo Zhou (Author), Dongyang Tang (Author), Lin He (Author), Shiqi Lin (Author), Josh Haipeng Lei (Author), Heng Sun (Author), Xiaoling Xu (Author), Chu-Xia Deng (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug combination therapy is a highly effective approach for enhancing the therapeutic efficacy of anti-cancer drugs and overcoming drug resistance. However, the innumerable possible drug combinations make it impractical to screen all synergistic drug pairs. Moreover, biological insights into synergi...