PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling

• Main Authors: Yan-Jun Cao (Author), Jing-Yan Li (Author), Pan-Xia Wang (Author), Zhi-Rong Lin (Author), Wen-Jing Yu (Author), Ji-Guo Zhang (Author), Jing Lu (Author), Pei-Qing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (Dox) is a chemotherapeutic drug used to treat a wide range of cancers, but its clinical application is limited due to its cardiotoxicity. Protein kinase C-ζ (PKC-ζ) is a serine/threonine kinase belonging to atypical protein kinase C (PKC) subfamily, and is activated by its phosphorylati...