PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling

• Автори: Yan-Jun Cao (Автор), Jing-Yan Li (Автор), Pan-Xia Wang (Автор), Zhi-Rong Lin (Автор), Wen-Jing Yu (Автор), Ji-Guo Zhang (Автор), Jing Lu (Автор), Pei-Qing Liu (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Doxorubicin (Dox) is a chemotherapeutic drug used to treat a wide range of cancers, but its clinical application is limited due to its cardiotoxicity. Protein kinase C-ζ (PKC-ζ) is a serine/threonine kinase belonging to atypical protein kinase C (PKC) subfamily, and is activated by its phosphorylati...