One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF<sup>V600E</sup> Inhibitors

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF<sup>V600E</sup> Inhibitors

In this investigation, novel 4-((quinolin-4-yl)amino)-thia-azaspiro[4.4/5]alkan-3-ones were synthesized via interactions between 4-(2-cyclodenehydrazinyl)quinolin-2(1<i>H</i>)-one and thioglycolic acid catalyzed by thioglycolic acid. We prepared a new family of spiro-thiazolidinone deriv...

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Main Authors: Lamya H. Al-Wahaibi (Author), Essmat M. El-Sheref (Author), Mohamed M. Hammouda (Author), Bahaa G. M. Youssif (Author)
Format: Book
Published: MDPI AG, 2023-03-01T00:00:00Z.
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