Characterization of NADPH Oxidase Expression and Activity in Acute Myeloid Leukemia Cell Lines: A Correlation with the Differentiation Status

• Main Authors: Hassan Dakik (Author), Maya El Dor (Author), Joan Leclerc (Author), Farah Kouzi (Author), Ali Nehme (Author), Margaux Deynoux (Author), Christelle Debeissat (Author), Georges Khamis (Author), Elfi Ducrocq (Author), Aida Ibrik (Author), Marie-José Stasia (Author), Houssam Raad (Author), Hamid Reza Rezvani (Author), Fabrice Gouilleux (Author), Kazem Zibara (Author), Olivier Herault (Author), Frédéric Mazurier (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In acute myeloid leukemia (AML), a low level of reactive oxygen species (ROS) is associated with leukemic stem cell (LSC) quiescence, whereas a high level promotes blast proliferation. ROS homeostasis relies on a tightly-regulated balance between the antioxidant and oxidant systems. Among the oxidan...