Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease

• Main Authors: Giulia Birolini (Author), Marta Valenza (Author), Ilaria Ottonelli (Author), Francesca Talpo (Author), Lucia Minoli (Author), Andrea Cappelleri (Author), Mauro Bombaci (Author), Claudio Caccia (Author), Caterina Canevari (Author), Arianna Trucco (Author), Valerio Leoni (Author), Alice Passoni (Author), Monica Favagrossa (Author), Maria Rosaria Nucera (Author), Laura Colombo (Author), Saverio Paltrinieri (Author), Renzo Bagnati (Author), Jason Thomas Duskey (Author), Riccardo Caraffi (Author), Maria Angela Vandelli (Author), Franco Taroni (Author), Mario Salmona (Author), Eugenio Scanziani (Author), Gerardo Biella (Author), Barbara Ruozi (Author), Giovanni Tosi (Author), Elena Cattaneo (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here we tested the long-term efficacy of chronic...