Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease

• Главные авторы: Giulia Birolini (Автор), Marta Valenza (Автор), Ilaria Ottonelli (Автор), Francesca Talpo (Автор), Lucia Minoli (Автор), Andrea Cappelleri (Автор), Mauro Bombaci (Автор), Claudio Caccia (Автор), Caterina Canevari (Автор), Arianna Trucco (Автор), Valerio Leoni (Автор), Alice Passoni (Автор), Monica Favagrossa (Автор), Maria Rosaria Nucera (Автор), Laura Colombo (Автор), Saverio Paltrinieri (Автор), Renzo Bagnati (Автор), Jason Thomas Duskey (Автор), Riccardo Caraffi (Автор), Maria Angela Vandelli (Автор), Franco Taroni (Автор), Mario Salmona (Автор), Eugenio Scanziani (Автор), Gerardo Biella (Автор), Barbara Ruozi (Автор), Giovanni Tosi (Автор), Elena Cattaneo (Автор)
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• Опубликовано: Elsevier, 2023-08-01T00:00:00Z.
• Предметы: article
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Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here we tested the long-term efficacy of chronic...