PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways

• Main Authors: Hongyong Fu (Author), Wenhui Zhang (Author), Qingqing Yuan (Author), Minghui Niu (Author), Fan Zhou (Author), Qianqian Qiu (Author), Guoping Mao (Author), Hong Wang (Author), Liping Wen (Author), Min Sun (Author), Zheng Li (Author), Zuping He (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spermatogonial stem cells (SSCs) have significant applications in reproductive and regenerative medicine. However, nothing is known about genes in mediating human SSCs. Here we have explored for the first time the function and mechanism of P21-activated kinase 1 (PAK1) in regulating the proliferatio...