ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

• Main Authors: Edward F. Griffin (Author), Samuel E. Scopel (Author), Cayman A. Stephen (Author), Adam C. Holzhauer (Author), Madeline A. Vaji (Author), Ryan A. Tuckey (Author), Laura A. Berkowitz (Author), Kim A. Caldwell (Author), Guy A. Caldwell (Author)
• Format: Book
• Published: The Company of Biologists, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform APOEε2 is associated with reduced risk, while APOEε3 is neutral and APOEε4 carriers exhibit increased susceptibility...