Fluorofenidone Attenuates Oxidative Stress and Renal Fibrosis in Obstructive Nephropathy via Blocking NOX2 (gp91phox) Expression and Inhibiting ERK/MAPK Signaling Pathway

• Main Authors: Jiao Qin (Author), Wen-Juan Mei (Author), Yan-Yun Xie (Author), Ling Huang (Author), Qiong-Jing Yuan (Author), Gao-Yun Hu (Author), Li-Jian Tao (Author), Zhang-Zhe Peng (Author)
• Format: Book
• Published: Karger Publishers, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: We evaluated the therapeutic effects of fluorofenidone (AKF-PD), a novel pyridone agent, targeting oxidative stress and fibrosis in obstructive nephropathy. Methods: AKF-PD was used to treat renal interstitial fibrosis in unilateral ureteral obstruction (UUO) obstructive nephropathy...