Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity

• Glavni autori: Sarah J. Annesley (Autor), Sui T. Lay (Autor), Shawn W. De Piazza (Autor), Oana Sanislav (Autor), Eleanor Hammersley (Autor), Claire Y. Allan (Autor), Lisa M. Francione (Autor), Minh Q. Bui (Autor), Zhi-Ping Chen (Autor), Kevin R. W. Ngoei (Autor), Flora Tassone (Autor), Bruce E. Kemp (Autor), Elsdon Storey (Autor), Andrew Evans (Autor), Danuta Z. Loesch (Autor), Paul R. Fisher (Autor)
• Format: Knjiga
• Izdano: The Company of Biologists, 2016-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

In combination with studies of post-mortem Parkinson's disease (PD) brains, pharmacological and genetic models of PD have suggested that two fundamental interacting cellular processes are impaired - proteostasis and mitochondrial respiration. We have re-examined the role of mitochondrial dysfun...