Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

• Main Authors: Amy Q. Wang (Author), Natalie R. Hagen (Author), Elias C. Padilha (Author), Mengbi Yang (Author), Pranav Shah (Author), Catherine Z. Chen (Author), Wenwei Huang (Author), Pramod Terse (Author), Philip Sanderson (Author), Wei Zheng (Author), Xin Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preclinical pharmacokinetics (PK) and In Vitro ADME properties of GS-441524, a potential oral agent for the treatment of Covid-19, were studied. GS-441524 was stable in vitro in liver microsomes, cytosols, and hepatocytes of mice, rats, monkeys, dogs, and humans. The plasma free fractions of GS-4415...