Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis

• প্রধান লেখক: Hilde J.G. Smits (লেখক), Justin E. Swartz (লেখক), Marielle E.P. Philippens (লেখক), Remco de Bree (লেখক), Johannes H.A.M. Kaanders (লেখক), Sjors A. Koppes (লেখক), Gerben E. Breimer (লেখক), Stefan M. Willems (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objectives: This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for immunohistochemical hypoxia markers with a nuclear (hypoxia-inducible factor 1α [HIF-1α]) and a cytoplasmic (pimonidazole [PIMO]) staining patter...