Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis

• मुख्य लेखकों: Hilde J.G. Smits (लेखक), Justin E. Swartz (लेखक), Marielle E.P. Philippens (लेखक), Remco de Bree (लेखक), Johannes H.A.M. Kaanders (लेखक), Sjors A. Koppes (लेखक), Gerben E. Breimer (लेखक), Stefan M. Willems (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for immunohistochemical hypoxia markers with a nuclear (hypoxia-inducible factor 1α [HIF-1α]) and a cytoplasmic (pimonidazole [PIMO]) staining patter...