Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis

• Автори: Hilde J.G. Smits (Автор), Justin E. Swartz (Автор), Marielle E.P. Philippens (Автор), Remco de Bree (Автор), Johannes H.A.M. Kaanders (Автор), Sjors A. Koppes (Автор), Gerben E. Breimer (Автор), Stefan M. Willems (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objectives: This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for immunohistochemical hypoxia markers with a nuclear (hypoxia-inducible factor 1α [HIF-1α]) and a cytoplasmic (pimonidazole [PIMO]) staining patter...