Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency

• Main Authors: Xiao Sun (Author), Shuangshan Dong (Author), Hiroki Kato (Author), Jun Kong (Author), Yosuke Ito (Author), Yuta Hirofuji (Author), Hiroshi Sato (Author), Takahiro A. Kato (Author), Yasunari Sakai (Author), Shouichi Ohga (Author), Satoshi Fukumoto (Author), Keiji Masuda (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial fission factor (MFF) is an adapter that targets dynamin-related protein 1 from the cytosol to the mitochondria for fission. Loss-of-function MFF mutations cause encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2). To elucidate the molecular mechanisms that w...