Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

• Main Authors: Anouk M. La Rose (Author), Venetia Bazioti (Author), Joanne A. Hoogerland (Author), Arthur F. Svendsen (Author), Anouk G. Groenen (Author), Martijn van Faassen (Author), Martijn G.S. Rutten (Author), Niels J. Kloosterhuis (Author), Bertien Dethmers-Ausema (Author), J. Hendrik Nijland (Author), Gilles Mithieux (Author), Fabienne Rajas (Author), Folkert Kuipers (Author), Michaël V. Lukens (Author), Oliver Soehnlein (Author), Maaike H. Oosterveer (Author), Marit Westerterp (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims to prevent hypoglycemia,...