Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment

• Main Authors: Khaled M. Hosny (Author), Waleed Y. Rizg (Author), Hala M. Alkhalidi (Author), Walaa A. Abualsunun (Author), Rana B. Bakhaidar (Author), Alshaimaa M. Almehmady (Author), Adel F. Alghaith (Author), Sultan Alshehri (Author), Amani M. El Sisi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Natamycin (NT) is a synthetic broad-spectrum antifungal used in eye drops. However, it has low solubility and high molecular weight, limiting its permeation, and generally causes eye discomfort or irritation when administered. Therefore, the present study aimed to develop an ophthalmic in situ gel f...