Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment

• Главные авторы: Khaled M. Hosny (Автор), Waleed Y. Rizg (Автор), Hala M. Alkhalidi (Автор), Walaa A. Abualsunun (Автор), Rana B. Bakhaidar (Автор), Alshaimaa M. Almehmady (Автор), Adel F. Alghaith (Автор), Sultan Alshehri (Автор), Amani M. El Sisi (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Natamycin (NT) is a synthetic broad-spectrum antifungal used in eye drops. However, it has low solubility and high molecular weight, limiting its permeation, and generally causes eye discomfort or irritation when administered. Therefore, the present study aimed to develop an ophthalmic in situ gel f...