Physiologically‐based pharmacokinetic pharmacodynamic parent‐metabolite model of edoxaban to predict drug-drug‐disease interactions: M4 contribution

Abstract This study aimed to develop a physiologically‐based pharmacokinetic pharmacodynamic (PBPK/PD) parent‐metabolite model of edoxaban, an oral anticoagulant with a narrow therapeutic index, and to predict pharmacokinetic (PK)/PD profiles and potential drug-drug‐disease interactions (DDDIs) in p...

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Main Authors: Ruijuan Xu (Author), Wenyuan Liu (Author), Weihong Ge (Author), Hua He (Author), Qing Jiang (Author)
Format: Book
Published: Wiley, 2023-08-01T00:00:00Z.
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