Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

• Main Authors: Shahar Azar (Author), Shiran Udi (Author), Adi Drori (Author), Rivka Hadar (Author), Alina Nemirovski (Author), Kiran V. Vemuri (Author), Maya Miller (Author), Dana Sherill-Rofe (Author), Yhara Arad (Author), Devorah Gur-Wahnon (Author), Xiaoling Li (Author), Alexandros Makriyannis (Author), Danny Ben-Zvi (Author), Yuval Tabach (Author), Iddo Z. Ben-Dov (Author), Joseph Tam (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The endocannabinoid (eCB) system is increasingly recognized as being crucially important in obesity-related hepatic steatosis. By activating the hepatic cannabinoid-1 receptor (CB1R), eCBs modulate lipogenesis and fatty acid oxidation. However, the underlying molecular mechanisms are larg...