Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

• Asıl Yazarlar: Shahar Azar (Yazar), Shiran Udi (Yazar), Adi Drori (Yazar), Rivka Hadar (Yazar), Alina Nemirovski (Yazar), Kiran V. Vemuri (Yazar), Maya Miller (Yazar), Dana Sherill-Rofe (Yazar), Yhara Arad (Yazar), Devorah Gur-Wahnon (Yazar), Xiaoling Li (Yazar), Alexandros Makriyannis (Yazar), Danny Ben-Zvi (Yazar), Yuval Tabach (Yazar), Iddo Z. Ben-Dov (Yazar), Joseph Tam (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2020-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: The endocannabinoid (eCB) system is increasingly recognized as being crucially important in obesity-related hepatic steatosis. By activating the hepatic cannabinoid-1 receptor (CB1R), eCBs modulate lipogenesis and fatty acid oxidation. However, the underlying molecular mechanisms are larg...