Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

• Main Authors: Laura Buyssens (Author), Allan Valenzuela (Author), Sara Prims (Author), Miriam Ayuso (Author), Thomas Thymann (Author), Chris Van Ginneken (Author), Steven Van Cruchten (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite considerable progress in understanding drug metabolism in the human pediatric population, data remains scarce in preterm neonates. Improving our knowledge of the ADME properties in this vulnerable age group is of utmost importance to avoid suboptimal dosing, which may lead to adverse drug re...