Mind the Gap-Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

• Main Authors: Theresa Noonan (Author), Katrin Denzinger (Author), Valerij Talagayev (Author), Yu Chen (Author), Kristina Puls (Author), Clemens Alexander Wolf (Author), Sijie Liu (Author), Trung Ngoc Nguyen (Author), Gerhard Wolber (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered questions in the field leave significant gaps in our understanding of their nuanced structure and function. Three-dimensional pharmacophore models are powerful computat...