Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline

• Asıl Yazarlar: Konstantinos Stamatopoulos (Yazar), Connor O'Farrell (Yazar), Mark J. H. Simmons (Yazar), Hannah K. Batchelor (Yazar), Nena Mistry (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus^® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrating dissolution profiles mea...