Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice

• Main Authors: Lilia Zurkovsky (Author), Evgeny Bychkov (Author), Elviche L. Tsakem (Author), Carley Siedlecki (Author), Randy D. Blakely (Author), Eugenia V. Gurevich (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY A subset of patients with Parkinson's disease acquires a debilitating dementia characterized by severe cognitive impairments (i.e. Parkinson's disease dementia; PDD). Brains from PDD patients show extensive cholinergic loss as well as dopamine (DA) depletion. We used a mutant mouse...