Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model

• Main Authors: Suchandan Sikder (Author), Georgina Price (Author), Md Abdul Alim (Author), Anil Gautam (Author), Robert Scott Simpson (Author), Catherine Margaret Rush (Author), Brenda Lee Govan (Author), Natkunam Ketheesan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune mediated diseases triggered by group A streptococcal (GAS) infections. Molecular mimicry between GAS M-proteins and host tissue proteins has been proposed as the mechanism that initiates autoreactive immune responses in ARF...