Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle

• Main Authors: Ruidong Xiang (Author), Lingzhao Fang (Author), Shuli Liu (Author), Iona M. Macleod (Author), Zhiqian Liu (Author), Edmond J. Breen (Author), Yahui Gao (Author), George E. Liu (Author), Albert Tenesa (Author), Brett A. Mason (Author), Amanda J. Chamberlain (Author), Naomi R. Wray (Author), Michael E. Goddard (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) or RNA splicing (sVariants) are expected to signifi...