The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor

• Main Authors: Ignac Ovari (Author), Gabor Viczjan (Author), Tamas Erdei (Author), Barbara Takacs (Author), Vera Tarjanyi (Author), Judit Zsuga (Author), Miklos Szucs (Author), Zoltan Szilvassy (Author), Bela Juhasz (Author), Rudolf Gesztelyi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The receptorial responsiveness method (RRM) enables the estimation of a change in concentration of an (even degradable) agonist, near its receptor, via curve fitting to (at least) two concentration-effect (E/c) curves of a stable agonist. One curve should be generated before this change, and the oth...