The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

• Main Authors: Philippe Behe (Author), Juliet R. Foote (Author), Adam P. Levine (Author), Craig D. Platt (Author), Janet Chou (Author), Fernando Benavides (Author), Raif S. Geha (Author), Anthony W. Segal (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and...