The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

• Prif Awduron: Philippe Behe (Awdur), Juliet R. Foote (Awdur), Adam P. Levine (Awdur), Craig D. Platt (Awdur), Janet Chou (Awdur), Fernando Benavides (Awdur), Raif S. Geha (Awdur), Anthony W. Segal (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and...