PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

• Main Authors: Lin Wang (Author), Liyuan Chen (Author), Zheran Liu (Author), Yaofang Liu (Author), Mao Luo (Author), Ni Chen (Author), Xin Deng (Author), Yulin Luo (Author), Jing He (Author), Liping Zhang (Author), Michael A. Hill (Author), Rong Li (Author), Jianbo Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to oc...