Development of a radiolabeled site-specific single-domain antibody positron emission tomography probe for monitoring PD-L1 expression in cancer

• Main Authors: Yinfei Chen (Author), Shiyu Zhu (Author), Jiayu Fu (Author), Jianguo Lin (Author), Yan Sun (Author), Gaochao Lv (Author), Minhao Xie (Author), Tao Xu (Author), Ling Qiu (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite advances in immunotherapy for the treatment of cancers, not all patients can benefit from programmed cell death ligand 1 (PD-L1) immune checkpoint blockade therapy. Anti-PD-L1 therapeutic effects reportedly correlate with the PD-L1 expression level; hence, accurate detection of PD-L1 express...