Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

Harnessing the RNA interference pathway offers a new therapeutic modality; however, solutions to overcome biological barriers to small interfering RNA (siRNA) delivery are required for clinical translation. This work demonstrates, by direct northern and quantitative PCR (qPCR) detection, stability,...

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Main Authors: Borja Ballarín-González (Author), Frederik Dagnaes-Hansen (Author), Robert A Fenton (Author), Shan Gao (Author), San Hein (Author), Mingdong Dong (Author), Jørgen Kjems (Author), Kenneth A Howard (Author)
Format: Book
Published: Elsevier, 2013-01-01T00:00:00Z.
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