Calmodulin- and Ca2+-Dependent Facilitation and Inactivation of the CaV 1.2 Ca2+ Channels in Guinea-Pig Ventricular Myocytes

• Main Authors: Dong-Yun Han (Author), Etsuko Minobe (Author), Wu-Yang Wang (Author), Feng Guo (Author), Jian-Jun Xu (Author), Li-Ying Hao (Author), Masaki Kameyama (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The L-type Ca2+ channel (Ca V 1.2) shows clear Ca2+-dependent facilitation and inactivation. Here we have examined the effects of calmodulin (CaM) and Ca2+ on Ca2+ channel in guinea-pig ventricular myocytes in the inside-out patch mode, where rundown of the channels was controlled. At a free [Ca2+]...