Caveolin-1 Regulates Chemokine Receptor 5-Mediated Contribution of Bone Marrow-Derived Cells to Dermal Fibrosis

• Main Authors: Rebecca eLee (Author), Beth ePerry (Author), Jonathan eHeywood (Author), Charles eReese (Author), Michael eBonner (Author), Corey eHatfield (Author), Richard M Silver (Author), Richard P Visconti (Author), Stanley eHoffman (Author), Elena eTourkina (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In fibrotic diseases caveolin-1 underexpression in fibroblasts results in collagen overexpression and in monocytes leads to hypermigration. These profibrotic behaviors are blocked by the caveolin-1 scaffolding domain peptide (CSD) which compensates for caveolin-1 deficiency. Monocytes and fibroblast...