3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

The liver enzyme matriptase-2 is a multi-domain, transmembrane serine protease with an extracellular, C-terminal catalytic domain. Synthetic low-molecular weight inhibitors of matriptase-2 have potential as therapeutics to treat iron overload syndromes, in particular in patients with β-thalassemia....

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Main Authors: Polya G. Roydeva (Author), Anna-Madeleine Beckmann (Author), Marit Stirnberg (Author), Jožko Cesar (Author), Danijel Kikelj (Author), Janez Ilaš (Author), Michael Gütschow (Author)
Format: Book
Published: MDPI AG, 2016-01-01T00:00:00Z.
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3rd Floor Main Library

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