Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression

• Main Authors: Chenyang Huang (Author), Yue Jiang (Author), Jianjun Zhou (Author), Qiang Yan (Author), Ruiwei Jiang (Author), Xi Cheng (Author), Jun Xing (Author), Lijun Ding (Author), Jianxin Sun (Author), Guijun Yan (Author), Haixiang Sun (Author)
• Format: Book
• Published: BMC, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) and Nur77 are novel regu...