Utilization of Knockout Mice to Examine the Potential Role of Gastric Histamine H2-Receptors in Menetrier's Disease

• Main Authors: Toshiki Ogawa (Author), Kazuhiko Maeda (Author), Shunsuke Tonai (Author), Takashi Kobayashi (Author), Takeshi Watanabe (Author), Susumu Okabe (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Menetrier's disease is characterized by giant gastric folds with foveolar hyperplasia and cystic dilatation, hypoproteinemia, and enhanced mucus secretion. The etiology remains unresolved and an effective treatment has yet to be established. Here we show that histamine H2-receptor deficient mic...