Inhibitory Effects of Ramosetron, a Potent and Selective 5-HT3-Receptor Antagonist, on Conditioned Fear Stress-Induced Abnormal Defecation and Normal Defecation in Rats: Comparative Studies With Antidiarrheal and Spasmolytic Agents

• Main Authors: Takuya Hirata (Author), Toshiyuki Funatsu (Author), Yoshihiro Keto (Author), Shinobu Akuzawa (Author), Masao Sasamata (Author), Keiji Miyata (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effect of ramosetron, a potent serotonin (5-HT)3-receptor antagonist for irritable bowel syndrome with diarrhea, on conditioned fear stress (CFS)-induced defecation and normal (non-stressed) defecation in rats and compared ramosetron with the antidiarrheal agent loperamide and the sp...