Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

• Egile Nagusiak: Zachary W. Reichenbach (Egilea), Kelly DiMattio (Egilea), Suren Rajakaruna (Egilea), David Ambrose (Egilea), William D. Cornwell (Egilea), Ronald J. Tallarida (Egilea), Thomas Rogers (Egilea), Lee-Yu (Egilea), Ronald F. Tuma (Egilea), Sara Jane Ward (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid CB2 receptors reverses allodynia and hyperalg...