Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

• Main Authors: Zachary W. Reichenbach (Author), Kelly DiMattio (Author), Suren Rajakaruna (Author), David Ambrose (Author), William D. Cornwell (Author), Ronald J. Tallarida (Author), Thomas Rogers (Author), Lee-Yu (Author), Ronald F. Tuma (Author), Sara Jane Ward (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid CB2 receptors reverses allodynia and hyperalg...