A comparison of methods for studying the tumor microenvironment's spatial heterogeneity in digital pathology specimens

• Main Authors: Ines Panicou Nearchou (Author), Daniel Alexander Soutar (Author), Hideki Ueno (Author), David James Harrison (Author), Ognjen Arandjelovic (Author), Peter David Caie (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The tumor microenvironment is highly heterogeneous, and it is understood to affect tumor progression and patient outcome. A number of studies have reported the prognostic significance of tumor-infiltrating lymphocytes and tumor budding in colorectal cancer (CRC). However, the significanc...