Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery: Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling

• Main Authors: Shuhei Tomita (Author), Yoshitaka Kihira (Author), Masaki Imanishi (Author), Yayoi Fukuhara (Author), Yuko Imamura (Author), Keisuke Ishizawa (Author), Yasumasa Ikeda (Author), Koichiro Tsuchiya (Author), Toshiaki Tamaki (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations. A major mechanism mediating adaptive responses to reduced oxygen availability is the regulation of transcription...