Association of the Serotonin and Kynurenine Pathways as Possible Therapeutic Targets to Modulate Pain in Patients with Fibromyalgia

• Main Authors: Alfonso Alfaro-Rodríguez (Author), Samuel Reyes-Long (Author), Ernesto Roldan-Valadez (Author), Maykel González-Torres (Author), Herlinda Bonilla-Jaime (Author), Cindy Bandala (Author), Alberto Avila-Luna (Author), Antonio Bueno-Nava (Author), Elizabeth Cabrera-Ruiz (Author), Pedro Sanchez-Aparicio (Author), Angélica González Maciel (Author), Ana Lilia Dotor-Llerena (Author), José Luis Cortes-Altamirano (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibromyalgia (FM) is a disorder characterized by widespread chronic pain, significant depression, and various neural abnormalities. Recent research suggests a reciprocal exacerbation mechanism between chronic pain and depression. In patients with FM, dysregulation of tryptophan (Trp) metabolism has...