Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

Abstract Background Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNV...

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Autores principales: Yanding Zhao (Autor), Robert Carter (Autor), Sivaraman Natarajan (Autor), Frederick S. Varn (Autor), Duane A. Compton (Autor), Charles Gawad (Autor), Chao Cheng (Autor), Kristina M. Godek (Autor)
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Publicado: BMC, 2019-05-01T00:00:00Z.
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