Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

• Autores principales: Yanding Zhao (Autor), Robert Carter (Autor), Sivaraman Natarajan (Autor), Frederick S. Varn (Autor), Duane A. Compton (Autor), Charles Gawad (Autor), Chao Cheng (Autor), Kristina M. Godek (Autor)
• Formato: Libro
• Publicado: BMC, 2019-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNV...