Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

• Main Authors: Yanding Zhao (Author), Robert Carter (Author), Sivaraman Natarajan (Author), Frederick S. Varn (Author), Duane A. Compton (Author), Charles Gawad (Author), Chao Cheng (Author), Kristina M. Godek (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intra-tumor heterogeneity stems from genetic, epigenetic, functional, and environmental differences among tumor cells. A major source of genetic heterogeneity comes from DNA sequence differences and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNV...