No association between polymorphisms in the <it>BDNF </it>gene and age at onset in Huntington disease
<p>Abstract</p> <p>Background</p> <p>Recent evidence suggests that brain-derived neurotrophic factor (BDNF) is an attractive candidate for modifying age at onset (AO) in Huntington disease (HD). In particular, the functional Val66Met polymorphism appeared to exert a sig...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
BMC,
2006-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Recent evidence suggests that brain-derived neurotrophic factor (BDNF) is an attractive candidate for modifying age at onset (AO) in Huntington disease (HD). In particular, the functional Val66Met polymorphism appeared to exert a significant effect. Here we evaluate <it>BDNF </it>variability with respect to AO of HD using markers that represent the entire locus.</p> <p>Methods</p> <p>Five selected tagging polymorphisms were genotyped across a 65 kb region comprising the <it>BDNF </it>gene in a well established cohort of 250 unrelated German HD patients.</p> <p>Results</p> <p>Addition of <it>BDNF </it>genotype variations or one of the marker haplotypes to the effect of CAG repeat lengths did not affect the variance of the AO.</p> <p>Conclusion</p> <p>We were unable to verify a recently reported association between the functional Val66Met polymorphism in the <it>BDNF </it>gene and AO in HD. From our findings, we conclude that neither sequence variations in nor near the gene contribute significantly to the variance of AO.</p> |
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| Item Description: | 10.1186/1471-2350-7-79 1471-2350 |